Macitentan

Macitentan

Author: ApexBio

spu:

A1929

CAS:

441798-33-0

purity:

0.9953

shortsummary:

Endothelin (ET)(A) and ET(B) receptor antagonist

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Formula:

C19H20Br2N6O4S

M.Wt:

588.27

Chemical Name:

5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine

SMILES:

CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br

Solubility:

≥24.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Storage:

Store at -20°C

Physical Appearance:

A solid

DeliveryTime:

In stock

Dibutyryl-cAMP APExBIO

ShippingType:

Blue ice

description:

Macitentan is a new dual ETA/ETB endothelin (ET) receptor antagonist, with mean IC50 values of 0.5 ± 0.2 nM (n= 17) to inhibit the binding of 125I-ET-1 to recombinant ETA receptors, and of 391±182 nM (n= 17) for ETB receptors in Chinese hamster ovary cells [1].

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