Ixabepilone

Ixabepilone

Author: ApexBio

spu:

A3513

CAS:

219989-84-1

purity:

0.98

shortsummary:

Epothilone B analog;microtubule-stabilizing agent

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Synonyms:

Azaepothilone B; BMS 247550; BMS 247550-1; Ixempra

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Formula:

C27H42N2O5S

M.Wt:

506.7

Chemical Name:

(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione

SMILES:

C[C@H]([C@H](O)[C@@H](C)C(C(C)(C)[C@@H](O)C1)=O)CCC[C@]2(C)[C@@H](O2)C[C@@H](/C(C)=C/C3=CSC(C)=N3)NC1=O

Solubility:

≥22.25 mg/mL in DMSO; insoluble in H2O; ≥41.3 mg/mL in EtOH with gentle warming

Storage:

Store at -20°C

Physical Appearance:

A solid

DeliveryTime:

In stock

26305-03-3 site

ShippingType:

Blue ice

description:

Ixabepilone(BMS-247550), an epothilone B analog, is an orally bioavailable microtubule inhibitor [1]. It could bind to tubulin and promote tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis[2].

related websites:

APExBIO Technology LLC is a premier provider of Small Molecule Inhibitors/Activators, Compound Libraries, Peptides, Assay Kits, Fluorescent Labels, Enzymes, Modified Nucleotides, mRNA synthesis and various tools for Molecular Biology. We carry a broad product line in over 712 different research areas such as cancer, immunology, neurosciences, apoptosis and epigenetics etc. Based in USA (Houston, Texas), we have been serving the needs of customers across the world.